Herbalism 3.0

Herbalism 3.0 is our term for the new post-genomic paradigm of 21st century botanical medicine. It merges data regarding the influence of plant-derived compounds on molecular, metabolic and signaling pathways in health, its imbalances, and the herbal treatment itself, to create precision personalized interventions. This novel approach draws from traditional systems of herbal medicine, East and West, which emphasize energetic and constitutional analysis of the individual and includes extensive historical herbal pharmacotherpeutic use data. These elements are framed within a contemporary understanding of biological individuality in terms of genetic and epigentic features of both the host terrain and the specific molecular characteristics of any related pathology.

Herbalism 3.0 is a product of applying the lenses of systems biology and bioinformatics to our rapidly expanding scientific knowledgebase of the molecular effects of natural compounds on cell biology. This approach can be applied  – translationally – in clinical practice to attain previously unavailable benefits in real-time at the point of care for patients with complex and multi-system challenges exemplified by cancer.  Ongoing incorporation of new research continuously refines the tools of Herbalism 3.0, which shares both the syntax and vocabulary of the mainstream at the level of genomics, metabolomics and proteomics. This common language generates a congruence that renders our approach uniquely suitable for collaborative treatment strategies – with botanical compounds presenting new possibilities both for synergistically enhancing mainstream interventions – or at very least complementing them and antidoting unwanted adverse drug effects.

In parallel, our knowledge of the role of dietary factors in disease disposition and causation has also been transformed by the same sciences that underly the emergence of Herbalism 3.0. Today, traditional nutritional therapeutics has morphed into evidence-based nutrigenomics that is driving a new understanding of the mechanisms by which dietary compounds can modify phenotypic expression (proteomoics and metabolomics) of the genome. Individual polymorphisms and other bio-markers of pre-disease states can be evaluated to create personalized dietary strategies for the prevention of diet-related disease’ as well as the epigenetic modification of DNA expression, to normalize homeostasis in a wide range of pathologies including cancer.  Nutrigenomics is inseparable from Herbalism 3.0 as evidenced by the number of dietary-derived compounds, such as curcumin, used in our therapeutic interventions that have bridged the traverse from food ingredient via dietary supplementation into our modern materia medica.